The Tumor Biochemistry Group of the Italian Society of Biochemistry and Molecular Biology (SIB) is glad to announce the third meeting of the group:
"Understanding cancer metabolism: exploring tumor heterogeneity to advance cancer therapy"

The conference will be held on 29–30 June 2023 at University "Magna Græcia” of Catanzaro. The meeting gathers top experts in the fields of cancer metabolism, immunometabolism and metabolomics to dissect  biochemical mechanisms underlying molecular features of cancer metabolism. Cellular metabolism represents a fundamental process in biology. During cancerogenesis, cells, in the tumor microenvironment, undergo dramatic metabolic reprogramming, while acquire the abilities to proliferate and survive under prohibitive conditions. Cancer is a dynamic disease. As consequence, tumor landscape results in heterogeneous cells subsets exhibiting peculiar molecular signatures including those involving metabolism. Overall, tumor cell subpopulations might unveil, in their architecture, a high spatial and temporal heterogeneity. In this context exploring metabolic features within tumor heterogeneity might help to understand nature and relative role of the different cell subsets and identify novel therapeutic targets aiming to improve cancer therapy. We expect that participants could share novel ideas, novel data, discoveries and future perspective by oral and poster presentations, emphasizing challenges facing metabolic rewiring of cancer cells in the perspective of their peculiar heterogeneity.

Target Audience
The target audience for this conference is basic and translational scientists, both senior and young investigators with an interest in cancer metabolism and immunometabolism.

Invited speakers are international outstanding scientists in the field of metabolism and immunometabolism that have given  crucial contribution to understand the plethora of metabolic changes underlying cancer initiation, progression, and chemoresistance. Their studies and findings are often milestones in the field of cancer metabolism. Please see the section “Speakers” for a list of confirmed speakers. Click on a speaker to find out more.

Topics to be covered:
  • Cancer
  • Metabolic reprogramming
  • Immunometabolism
  • Targeted therapy
  • Mitochondria and Mitochondria epigenetics
  • Nuclear epigenetics
  • Combined therapy
  • Metabolomics
  • Modeling cancer metabolic rewiring
  • 3D cell models of cancer metabolism
  • In silico model of cancer metabolism

Scientific Programme Committe                                                                 
Prof. Ferdinando Chiaradonna                                                                   
Prof. Domenica Scumaci                                                                         
Prof. Francesco Saverio Costanzo
Prof. Giuseppe Viglietto
Prof. Giovanni Cuda
Prof. Ilaria Dando
Prof. Michela Grosso
Prof. Alessio Paone
Prof. Chiara Riganti
Prof. Federica Rizzi

Tumor Biochemistry group
The Tumor Biochemistry group of the Italian Society of Biochemistry and Molecular Biology (SIB), coordinated by Prof. Ferdinando Chiaradonna, focuses its attention on the biochemical and molecular mechanisms underlying the neoplastic transformation including cell differentiation process and its alterations. The group's research topics reflect its scientific heterogeneity. Several research topics are dissected in the group as follow: Biochemical mechanisms of neoplastic transformation and cell differentiation. Signaling and transformation, cell-to cell interactions. Oncogenes and oncosuppressors. Mutations, loss and gain of function. Cancer cell metabolism and its role in tumor formation and maintenance. Role of the cellular microenvironment in transformation, invasiveness and metastasis. Epigenetic modifications and transformation. Plasticity of the tumor cells. Differentiation and de-differentiation as cancer associated processes. Epithelium-mesenchymal and mesenchymal-epithelium transition. Cell cycle and death mechanisms in normal and cancer cells. Normal and cancer stem cells. Drug resistance. New anticancer drugs and their synergistic effects in vitro and in vivo. New cellular and animal models, respectful of the 3R principles for the study of transformation and differentiation (2D, 3D, animal
models other than mammals).

Organizing Committee
Prof. Domenica Scumaci
Prof. Ferdinando Chiaradonna

Prof. Daniele Tibullo
Prof. Concetta Maria Faniello
Prof. Valter Agosti
Prof. Carmela De Marco
Dr. Marina La Chimia
Dr. Barbara Zerbato
Dr. Virginia Brancato

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